| 王 勇,刘胜利.窄谱中波紫外线联合阿维A胶囊治疗斑块状银屑病疗效分析[J].中国烧伤创疡杂志,2024,(4):331~334. |
| DOI： |
| 中文关键词: 斑块状银屑病 窄谱中波紫外线 阿维 Ａ 胶囊 白细胞介素⁃17 白细胞介素⁃22 银屑病皮损面积和严重程度指数 |
| 英文关键词:Plaque psoriasis Narrow-spectrum medium-wave ultraviolet light Acitretin capsules Interleukin-17 Interleukin-22 Psoriasis area and severity index |
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| 中文摘要: |
| 【摘要】 目的 分析窄谱中波紫外线联合阿维A胶囊治疗斑块状银屑病的临床疗效。 方法 选取2021年5月至2022年5月永城市人民医院收治的92例斑块状银屑病患者作为研究对象, 按照不同治疗方法将其分为联合组(46例)和单一组(46例), 联合组患者采用窄谱中波紫外线联合阿维A胶囊治疗, 单一组患者单纯采用阿维A胶囊治疗, 对比观察两组患者皮损情况、血清炎症因子水平、临床疗效及不良反应发生情况。结果 治疗 8周后, 联合组患者银屑病皮损面积和严重程度指数 (PASI) 评分为 (7.53±1.86) 分、 血清白细胞介素 (IL) -17水平为 (40.78± 9.49) ng / ml、血清 IL-22 水平为 ( 29.61 ± 7.64) ng / ml, 明显低于单一组患者的 PASI 评分(11.82±2.45) 分、血清 IL-17 水平 ( 54.23± 11.62) ng / ml、 血清 IL-22 水平 ( 37.12± 8.76) ng / ml ( t = 9.459、6.080、4.382, P 均<0.001); 治疗8周后, 联合组患者治疗总有效率为 91.30%, 明显高于单一组患者的治疗总有效率 71.74% (χ2 = 5.845, P= 0.016); 治疗期间, 联合组患者不良反应发生率为 8.70%, 与单一组患者的不良反应发生率 15.22%无明显差异 (χ2 = 0.929, P= 0.335)。结论 与单纯应用阿维 A 胶囊相比, 窄谱中波紫外线联合阿维 A 胶囊更有利于调节斑块状银屑病患者的血清 IL-17、 IL-22 水平, 减轻炎症细胞浸润程度, 改善临床症状, 且安全性较好。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the clinical efficacy of narrow-spectrum medium-wave ultraviolet light combined with acitretin capsules in the treatment of plaque psoriasis. Methods 92 patients with plaque psoriasis, admitted to Yongcheng People’s Hospital from May 2021 to May 2022, were enrolled as research subjects and divided into the combination group (n = 46) and the single group (n = 46) according to the different treatment methods they received. Patients in the combination group were treated with narrow-spectrum medium-wave ultraviolet light combined with acitretin capsules, whereas patients in the single group were given acitretin capsules alone for treatment. The skin lesion condition, serum inflammatory factor levels, clinical efficacy and the occurrence of adverse reactions were compared between the two groups. Results After 8 weeks of treatment, patients in the combination group had a psoriasis area and severity index (PASI) score of (7.53± 1.86) points, serum interleukin (IL) -17 level of (40.78±9.49) ng / ml, and serum IL-22 level of (29.61±7.64) ng / ml, which were significantly lower than the corresponding (11.82±2.45) points, (54.23±11.62) ng / ml, and (37.12±8.76) ng / ml of patients in the single group ( t = 9.459, 6.080 and 4.382, all P<0.001), and the total effective rate of patients was 91.30% in the combination group, which was significantly higher than the corresponding 71.74% in the single group (χ2 =5.845, P= 0.016). During the treatment period, the incidence of adverse reactions of patients in the combination group was 8.70%, showing no significantly difference compared with the corresponding 15.22% in the single group (χ2 =0.929, P=0.335). Conclusion Compared with the alone application of acitretin capsules, the combined application of narrow-spectrum medium- wave ultraviolet light and acitretin capsules is more effective in regulating serum IL-17 and IL-22 levels of patients with plaque psoriasis, and improving their inflammatory cell infiltration and clinical symptoms, and is safe to apply in clinical practice. |
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