• 左卡尼汀联合肾脏替代治疗烧伤致急性肾衰竭疗效分析
  • Analysis of the therapeutic effect of levocarnitine combined with renal replacement therapy on acute renal failure caused by burns
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    中文关键词:  左卡尼汀  烧伤  肾脏替代  急性肾衰竭  氧化应激  心功能  营养状态
    英文关键词:L-carnitine  burn  Renal replacement  Acute renal failure  Oxidative stress  Heart function  Nutritional status
    基金项目:
    作者单位邮编
    刘畅* 商丘市第一人民医院 476000
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    中文摘要:
          目的 分析左卡尼汀联合肾脏替代治疗烧伤致急性肾衰竭的疗效。方法 选取2021年1月至2024年7月收治60例的烧伤致急性肾衰竭患者为研究对象。按照随机数表法将其随机分为研究组与对照组,每组30例。对照组患者行肾脏替代治疗,研究组患者行左卡尼汀联合肾脏替代治疗,比较两组临床疗效。结果 治疗5 d后,研究组患者MDA水平低于对照组,GSH-Px、SOD、LVEF、白蛋白、铁蛋白、RBC、Hct、Hb水平高于对照组(P<0.05)。结论 左卡尼汀联合肾替代治疗可降低烧伤致急性肾衰竭患者机体氧化应激反应,促进蛋白质合成,减少蛋白质溶解,提高心肌能量储备,明显改善机体血氧状态。
    英文摘要:
          Objective: To analyze the efficacy of combination therapy of levocarnitine and renal replacement therapy for acute renal failure caused by burns. Method: Sixty patients with burn induced acute kidney failure admitted from January 2021 to July 2024 were selected as the research subjects. According to the random number table method, they were randomly divided into a study group and a control group, with 30 cases in each group. The control group received renal replacement therapy, while the study group received a combination of levocarnitine and renal replacement therapy. The clinical efficacy of the two groups was compared. After 5 days of treatment, the MDA levels in the study group were lower than those in the control group, GSH-Px、SOD、LVEF、 The levels of albumin, ferritin, RBC, Hct, and Hb were higher than those in the control group (P<0.05). Conclusion: The combination of L-carnitine and renal replacement therapy can reduce oxidative stress response, promote protein synthesis, reduce protein dissolution, improve myocardial energy reserve, and significantly improve blood oxygen status in patients with burn induced acute kidney failure.